Our lab studies how molecular mechanisms quantitatively regulate cellular functions and organismal phenotypes in mice and humans. Specifically, we investigate the molecular mechanisms regulating and coordinating individual hematopoietic stem and progenitor cells in blood and immune cell production. We leverage this model system to precisely quantify and dynamically track blood and immune cell regeneration across molecular, cellular, tissue, and organismal levels. Our interdisciplinary research emphasizes in vivo cellular heterogeneity, leveraging quantitative and systems biology approaches. We integrate innovative experimental and computational methods, including in vivo clonal tracking with transgenic mouse models and primary human samples, as well as machine learning algorithms and mathematical modeling.