Lab Overview

Our lab studies how molecular mechanisms quantitatively regulate cellular functions and organismal phenotypes in mice and humans. Despite substantial advancements in elucidating the regulation and interaction of various molecular processes, it remains challenging to relate these molecular insights to quantifiable cellular and tissue functions in mammals. To address this critical knowledge gap, our research group investigates the molecular mechanisms regulating hematopoietic stem cells (HSCs) in blood and immune cell production. We leverage this model system to precisely quantify and dynamically track blood and immune cell regeneration across molecular, cellular, tissue, and organismal levels. Our interdisciplinary research emphasizes quantitative and systems biology approaches, integrating experimental and computational methods such as in vivo clonal tracking with transgenic mouse models and primary human samples, alongside machine learning algorithms and mathematical modeling.