Why does a leukemic mutation not always lead to leukemia? A new clue from a mouse study at USC

From left, study authors Jiya Eerdeng, Ivon Garcia, Rong Lu, Charles Bramlett, Mary Vergel-Rodriguez, and Yeachan Lee (Photo by Bowen Wang)
From left, study authors Jiya Eerdeng, Ivon Garcia, Rong Lu, Charles Bramlett, Mary Vergel-Rodriguez, and Yeachan Lee (Photo by Bowen Wang)
Why do some people with a genetic mutation associated with leukemia remain healthy, while others with the same mutation develop the blood cancer? In a new study published in Blood, scientists from the USC Stem Cell laboratory of Rong Lu discovered a mechanism that linked a leukemic mutation to varying potentials for disease developmentā€”a discovery which could eventually lead to a way to identify patients with the mutation who are most at risk.

To read more, visit https://stemcell.keck.usc.edu/leukemic-mutation-does-not-always-lead-to-leukemia/.